Cape Town's most popular sports by participation are cricket, association football, swimming, and rugby union. The Stormers represent Western Province and Boland Cavaliers in the Southern Hemisphere's Super 14 rugby union competition. Cape Town is the home of the Western Province Rugby Union, who play at Newlands Stadium and compete in the Currie Cup. Cape Town also regularly hosts the national team, the Springboks, and hosted matches during the 1995 Rugby World Cup, including a semi-final.

Association football, which is better known as soccer in South Africa, is also popular. Two clubs from Cape Town play in the Premier Soccer League (PSL), South Africa's premier league. These teams are Ajax Cape Town, which formed as a result of the 1999 amalgamation of the Seven Stars and the Cape Town Spurs; and Santos. Cape Town will also be the location of several of the matches of the FIFA 2010 World Cup including a semi-final, which is to be held in South Africa. The Mother City is building a new 70,000 seat stadium (Green Point Stadium) in the Green Point area.

In cricket, the Cape Cobras represent Cape Town at the Newlands Cricket Ground. The team is the result of an amalgamation of the Western Province Cricket and Boland Cricket teams. They take part in the Supersport and Standard Bank Cup Series.

Cape Town has Olympic aspirations: in 1996, Cape Town was one of the five candidate cities short listed by the IOC to launch official candidatures to host the 2004 Summer Olympics. Although the games ultimately went to Athens, Cape Town came in third place. There has been some speculation that Cape Town is seeking the South African Olympic Committee's nomination to be South Africa's bid city for the 2020 Summer Olympic Games.